Influenza virus infections represent a big issue for public health since effective treatments are still
lacking. In particular, the emergence of strains resistant to drugs limits the effectiveness of anti-influenza
agents. For this reason, many efforts have been dedicated to the identification of new therapeutic strategies aimed at targeting
the virus-host cell interactions. Oxidative stress is a characteristic of some viral infections including influenza. Because
antioxidants defend cells from damage caused by reactive oxygen species induced by different stimuli including
pathogens, they represent interesting molecules to fight infectious diseases. However, most of the available studies have
found that these would-be panaceas could actually exacerbate the diseases they claim to prevent, and have thus revealed
"the dark side" of these molecules. This review article discusses the latest opportunities and drawbacks of the antioxidants
used in anti-influenza therapy and new perspectives.
Keywords: Anti-influenza therapy, Antioxidants, Antivirals, Influenza virus, Oxidative stress, Redox state.
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