Abstract
This contribution gives an overview of recent insights and emerging strategies for individualized therapeutic approaches based on genomic and cancer molecular profiles in patients with a morphological diagnosis of renal, bladder and prostate tumors. Significant advances have been made in molecular biology technologies, such as next-generation sequencing and whole-exome sequencing. The rise of such novel techniques has increased our knowledge on tumor cell biology and cancer development, thus allowing us to identify complex genomic abnormalities. These findings have paved the way to provide healthcare from an individual perspective. An emerging strategy to individualize therapeutic interventions is focused on stem cells. Because of their unique characteristics, they are among the most promising candidates as potential vectors carrying suicide genes into different types of cancer, including genitourinary tumors. Another emerging strategy could be based on prostate specific membrane antigen (PSMA), a unique membrane-bound glycoprotein, which is overexpressed manifold in prostate cancer. PSMA can serve as target for delivering therapeutic agents such as cytotoxins or radionuclides.
Keywords: Bladder cancer, beasholer cancer, genito-urinary cancers, kidney cancer, molecular pathology, personalized therapies, prostate cancer, urogenital pathology.
Current Drug Targets
Title:Morphologic and Molecular Backgrounds for Personalized Management of Genito-Urinary Cancers: An Overview
Volume: 16 Issue: 2
Author(s): Rodolfo Montironi, Matteo Santoni, Antonio Lopez-Beltran, Liang Cheng, Holger Moch and Marina Scarpelli
Affiliation:
Keywords: Bladder cancer, beasholer cancer, genito-urinary cancers, kidney cancer, molecular pathology, personalized therapies, prostate cancer, urogenital pathology.
Abstract: This contribution gives an overview of recent insights and emerging strategies for individualized therapeutic approaches based on genomic and cancer molecular profiles in patients with a morphological diagnosis of renal, bladder and prostate tumors. Significant advances have been made in molecular biology technologies, such as next-generation sequencing and whole-exome sequencing. The rise of such novel techniques has increased our knowledge on tumor cell biology and cancer development, thus allowing us to identify complex genomic abnormalities. These findings have paved the way to provide healthcare from an individual perspective. An emerging strategy to individualize therapeutic interventions is focused on stem cells. Because of their unique characteristics, they are among the most promising candidates as potential vectors carrying suicide genes into different types of cancer, including genitourinary tumors. Another emerging strategy could be based on prostate specific membrane antigen (PSMA), a unique membrane-bound glycoprotein, which is overexpressed manifold in prostate cancer. PSMA can serve as target for delivering therapeutic agents such as cytotoxins or radionuclides.
Export Options
About this article
Cite this article as:
Montironi Rodolfo, Santoni Matteo, Lopez-Beltran Antonio, Cheng Liang, Moch Holger and Scarpelli Marina, Morphologic and Molecular Backgrounds for Personalized Management of Genito-Urinary Cancers: An Overview, Current Drug Targets 2015; 16 (2) . https://dx.doi.org/10.2174/1389450115666141202113805
DOI https://dx.doi.org/10.2174/1389450115666141202113805 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Exploring Polypharmacology in Drug Discovery and Repurposing Using the CANDO Platform
Current Pharmaceutical Design Melatonin and Melatoninergic Drugs as Therapeutic Agents: Ramelteon and Agomelatine, the Two Most Promising Melatonin Receptor Agonists
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Novel Systemic Drugs for Cutaneous T-Cell Lymphoma
Recent Patents on Anti-Cancer Drug Discovery Statins and Alkylphospholipids as New Anticancer Agents Targeting Lipid Metabolism
Anti-Cancer Agents in Medicinal Chemistry Exploring Proteomic Drug Targets, Therapeutic Strategies and Protein - Protein Interactions in Cancer: Mechanistic View
Current Cancer Drug Targets The Klf6 Super-enhancer Determines Klf6 Sensitivity to BRD4 Inhibitors in Human Hepatoma (HepG2) Cells
Current Biotechnology Targeting Cellular Proapoptotic Molecules for Developing Anticancer Agents from Marine Sources
Current Drug Targets Osteoblast Differentiation and Control by Vitamin D and Vitamin D Metabolites
Current Pharmaceutical Design Unmet Needs in Ovarian Cancer: Dividing Histologic Subtypes to Exploit Novel Targets and Pathways
Current Cancer Drug Targets Daidzein and its Effects on Brain
Current Medicinal Chemistry Prostate Cancer: Biology, Incidence, Detection Methods, Treatment Methods, and Vaccines
Current Topics in Medicinal Chemistry Current Development of Metal Complexes with Diamine Ligands as Potential Anticancer Agents
Current Medicinal Chemistry A Conceptual Model of Psychoneurological Symptom Cluster Variation in Women with Breast Cancer: Bringing Nursing Research to Personalized Medicine
Current Pharmacogenomics and Personalized Medicine MicroRNAs in Cancer Gene Therapy: Another Look
Current Cancer Therapy Reviews Interaction of Biologically Active Amines with Mitochondria and Their Role in the Mitochondrial-Mediated Pathway of Apoptosis
Current Medicinal Chemistry Cytotoxic Compounds in the Treatment of Castration-Resistant Prostate Cancer
Anti-Cancer Agents in Medicinal Chemistry Mechanisms of Resistance to Photodynamic Therapy
Current Medicinal Chemistry Editorial (Hot Topic: Biomarkers of Oxidative Stress and Cancer: From Chemistry, Biology to Clinical Applications and Personalized Therapy)
Current Molecular Medicine Vitamin D Analogs in Cutaneous Malignancies
Current Pharmaceutical Design Biochemical and Pharmacological Applications of Essential Oils in Human Health Especially in Cancer Prevention
Anti-Cancer Agents in Medicinal Chemistry