Title:Synthesis and Preliminary Biological Evaluation of New Heterocyclic Carboxamide Models
VOLUME: 12 ISSUE: 5
Author(s):Kamal Sweidan, Jorn Engelmann, Walid Abu Rayyan, Dima Sabbah, Musa Abu Zarga, Dima Sabbah, Tariq Al-Qirim, Yusuf Al-Hiari, Ghassan Abu Sheikha and Ghassan Shattat
Affiliation:Department of Chemistry, The University of Jordan, Amman 11942, Jordan.
Keywords:Antifungal activity, cervical cancer cell, cytotoxicity, heterocyclic compounds, NMR, Synthesis.
Abstract:The heterocyclic system is a promising core nucleus in many bioactive compounds. This work describes our effort
to synthesize and characterize a set of new biphenyl, benzofuran and benzothiophene carboxamide derivatives. Our
biological studies showed that compounds 10 and 17 have antifungal activity against C. galabrate more potent than fluconazole
compounds 9, 10, and 17 exerted cytotoxic activities in immortalized embryonic mouse fibroblast cells (3T3)
and a human cervical cancer cell line (HeLa); in particular, the cyclic amidine derivative 17 showed selective toxicity
against HeLa. This study showed that the tested compounds have the potential to be useful as antitumor drugs after further
optimization.
