Title:Hydrogen Sulfide Regulates Vascular Inflammation and its Related Signaling Pathways
VOLUME: 9 ISSUE: 2
Author(s):Shasha Feng, Junbao Du, Selena Y. Chen, Wen Yu, Chaoshu Tang and Hongfang Jin
Affiliation:Department of Pediatrics, Peking University First Hospital, Xi-An Men Str. No.1, West District, Beijing 100034, P.R. China.
Keywords:Atherosclerosis, balloon injury, hydrogen sulfide, hypertension, inflammation, NF-κB pathway, pulmonary
hypertension.
Abstract:Hydrogen sulfide (H2S) is regarded as one of the air pollutants with a rotten egg smell. However, it
is recently discovered that endogenous H2S has important physiological and pathological functions.
Cystathionine- β synthase (CBS) and cystathionine- γ lyase (CSE) play key roles in the synthesis of H2S, and
CSE is also a major H2S-formation enzyme in the cardiovascular system. Vascular inflammation is one of the most
important pathological processes in a variety of vascular diseases. The present review aimed at exploring the role of
hydrogen sulfide and its signaling in vascular inflammation during vascular diseases including atherosclerosis, systemic
hypertension, pulmonary hypertension (PAH), and vascular balloon injury.
