A Mini Review on Biological Activities of Pyridazinone Derivatives as Antiulcer, Antisecretory, antihistamine and Particularly Against Histamine H3R

Author(s): Mohammad Asif

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 14 , Issue 13 , 2014

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Pyridazinone derivatives and their related analoges were introduced for gastric antiulcer and antisecretory activities. Selected compounds were applied to ulcer models and showed their antiulcer and anti secretary activities. Some pyridazinone compounds are recently reported as H3R antagonists. Some amine analogs of pyridazinones, pyridazinone– phenethylamines and 4,5-fused pyridazinones showed histamine H3R antagonist activity with significant affinity for rat and human H3R. These pyridazinone analogs also showed excellent selectivity and metabolic stability, with adequate pharmacokinetics.

Keywords: Antiulcer, antagonist, antisecretory, histamine, H3 receptor, pyridazinones.

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Article Details

Year: 2014
Page: [1093 - 1103]
Pages: 11
DOI: 10.2174/1389557514666141127143133
Price: $65

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PDF: 36