Epilepsy is a non-communicable central nervous system disorder that affects over 60 million people
worldwide. The developments in epilepsy treatment face major hurdles due to drug resistance and disease recurrence
after reduction in medication. Nano-technological anti-epileptic drug (AED) delivery systems have recently
garnered attention due to their ability to cross the blood brain barrier, improved selectivity and potential for sustained
drug delivery to the brain. This review focuses on several nano-based AED delivery systems, including
liposomes, nano-emulsions, polymeric nanoparticles, solid-lipid nanoparticles and magnetic nanoparticles. Their limitations and future
prospects in terms of AED delivery to the brain are also highlighted. It is hoped that the present communication will be helpful in the
identification of potential AED delivery systems based on their advantages and disadvantages.
Keywords: Epilepsy, liposomes, magnetic nanoparticles, nano-emulsions, polymeric nanoparticles, solid-lipid nanoparticles, therapy.
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