Methods of Estimating Hippocampal Volume Loss in Alzheimer’s Disease
Pp. 88-102 (15)
Vikas Dhikav, Kuljeet Singh Anand, Mansi Sethi and Umesh Chander Garga
Volumetric measurement of the Hippocampus is currently a growing and an
upcoming area for a number of neuropsychiatric disorders. In the recent years,
volumetric analysis of hippocampus in Alzheimer’s disease has received lot of attention
due to close association of this structure in pathophysiology of this devastating disease.
In the coming times, it may even be included as a formal part of clinical evaluation of
dementia. However, as an evolving technique it has some issues, limitations and areas
where agreement has not been achieved. Though now it is increasingly being practiced
and accepted - there are some issues that need attention of researchers in this field.
Some of the issues are: radiological definition i.e. what should be considered as
Hippocampus and how much area is to be included for manual volumetry. Also, the
development of population norms for a normative data for voxel based morphometry
remains a challenge. Present chapter reviews these methods and issues.
Hippocampal atrophy, hippocampal volume measurement,
hippocampus, magnetic resonance imaging, morphometry, volumetry.
Postgraduate Institute of Medical Education & Research (PGIMER) & Dr. Ram Manohar Lohia Hospital, New Delhi, 110001, India.