Tuberculosis is one of the leading global health issues responsible for a significant mortality. The emergence of
multidrug resistant (MDR), extensively drug resistant (XDR) and total drug resistant (TDR) strains have further hampered
the disease control. Drug resistance has emerged as imperative concern resulting in genetic selection of drug resistance
strains making them unresponsive to most of the drugs. In addition iron has been implicated in promoting Mycobacterium
tuberculosis (MTB) replication, infection and progression to clinical disease. ideR is an essential gene in Mycobacterium
tuberculosis and controls the transcription of mycobacterium by binding to promoters of ideR regulated gene in presence
of iron. Iron chelators have the potential to sequester this excess iron hence hampering MTB replication and restoring host
defence mechanisms. Iron chelators could be envisaged as promising candidates in iron overload associated prevention
and treatment of MTB.
Keywords: Drug resistance, iron, nanomedicine, tuberculosis.
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