Physiological Functions of Presenilins; Beyond γ-Secretase

Author(s): Ibolya Stiller, Beata Lizak, Gabor Banhegyi

Journal Name: Current Pharmaceutical Biotechnology

Volume 15 , Issue 11 , 2014

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Presenilin (PS) was identified in screens for mutations causing the early onset forms of familial Alzheimer's disease (FAD) in 1995. As catalytic units of the γ-secretase complex, presenilins participate in the processing of amyloid beta protein (Aβ), the main component of deposits in brain of patients with AD. The more than 90 substrates of γ-secretase isolated so far demonstrate its contribution to wide range of cellular processes and signaling events. However, recent findings have revealed numerous γ-secretase-independent presenilin functions, including involvement in calcium homeostasis, endoplasmic reticulum (ER) stress and autophagy. This mini-review attempts to summarize the multiple physiological and pathological functions of presenilin.

Keywords: Autophagy, Ca2+ signaling, presenilin, ER stress, γ-secretase, neurodegenerative disease.

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Article Details

Year: 2014
Page: [1019 - 1025]
Pages: 7
DOI: 10.2174/1389201015666141122204139
Price: $65

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