Molecular Imaging in Optical Coherence Tomography

Author(s): Scott P. Mattison, Wihan Kim, Jesung Park, Brian E. Applegate

Journal Name: Current Molecular Imaging (Discontinued)

Volume 3 , Issue 2 , 2014


Optical coherence tomography (OCT) is a medical imaging technique that provides tomographic images at micron scales in three dimensions and high speeds. The addition of molecular contrast to the available morphological image holds great promise for extending OCT’s impact in clinical practice and beyond. Fundamental limitations prevent OCT from directly taking advantage of powerful molecular processes such as fluorescence emission and incoherent Raman scattering. A wide range of approaches is being researched to provide molecular contrast to OCT. Here we review those approaches with particular attention to those that derive their molecular contrast directly from modulation of the OCT signal. We also provide a brief overview of the multimodal approaches to gaining molecular contrast coincident with OCT.

Keywords: Fluoresence imaging, magnetomotive, molecular imaging, optical coherence tomography, photothermal, pump-probe.

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Article Details

Year: 2014
Published on: 04 February, 2015
Page: [88 - 105]
Pages: 18
DOI: 10.2174/2211555203666141117233442
Price: $58

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