The objective of the present research was to cultivate an oral formulation of an anti-diabetic
drug using polymeric nanofiber. A biodegradable polymer i.e. poly (vinyl alcohol) (PVA) nanofiber
loaded linagliptin was prepared using electro spinning technique. The drug entrapment in the developed
nanofibers was confirmed by scanning electron microscopy and X-ray diraction. The in vivo
study was performed on male Wistar rats to establish the pharmacodynamics behavior of developed
formulation. The mucoadhesive strength results confirmed that the drug loaded PVA nanofiber patch
had the highest mucoadhesion strength compare to PVA film and blank PVA nanofiber, due to its
higher water holding capacity and surface area. The in vitro release study suggested that controlled release
array of the drug from the nanofiber patch. In vivo activity validated the fact that linagliptin was delivered in its active
state and showed visible results when compared to the commercial formulation. Additionally an encapsulation efficacy
of 92% of the experimental formulation provides sufficient suggestion that the nanofibers serve as an ideal carrier for
the delivery of linagliptin via the sublingual route.
Keywords: Anti-diabetic, nanofibers, polyvinyl alcohol, linagliptin, controlled release.
Rights & PermissionsPrintExport