Synthesis, Characterization, in vivo and in silico Studies of Antidepressant Activity of 2-chloro-4’methoxy Benzoin

Author(s): Balasundaram Thanuja, Charles C. Kanakam

Journal Name: Current Chemical Biology

Volume 8 , Issue 1 , 2014

Become EABM
Become Reviewer
Call for Editor


A new 2-chloro-4’methoxy benzoin (2C4MB) with chemical formula (C15H13ClO3) was synthesized by benzoin condensation. The single crystal XRD study of 2C4MB was also carried out in order to confirm its structure and conformation. The anti-depressant activity of 2C4MB was also carried out on albino mice as test animal. The results of the antidepressant studies of 2C4MB correlated with the docking calculations performed on proteins 3GWU, 3GWV, and 3GWW.

Keywords: Anti-depressant activity, benzoin condensation, histopathological assessment, molecular docking, single crystal XRD.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2014
Published on: 12 November, 2014
Page: [17 - 26]
Pages: 10
DOI: 10.2174/221279680801141112095300

Article Metrics

PDF: 25