Title:Chiral Bifunctional Ferrocenylphosphines as New Catalysts for aza- Morita-Baylis-Hillman Reactions of N-Sulfonated Imines with Methyl Vinyl Ketone
VOLUME: 2 ISSUE: 1
Author(s):Haiwen Hu, Qian Tang, Aiping Tu and Weihui Zhong
Affiliation:Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P.R. China.
Keywords:aza-MBH adducts, aza-Morita-Baylis-Hillman reaction, chiral bifunctional ferrocenylphosphines, organocatalyst.
Abstract:A series of new chiral bifunctional Ferrocenylphosphines was designed, synthesized and applied for
the asymmetric aza-Morita-Baylis-Hillman reaction of N-sulfonated imines with methyl vinyl ketone (MVK).
The reaction proceeded under mild conditions to afford the desired aza-MBH adducts in moderate to high
yields with up to 56% ee value.
