Background: To investigate the long term efficacy of carotid denervation by adventitial stripping of the internal
carotid artery (ICA) for carotid sinus syndrome (CSS). Secondly, the long term safety of this technique is investigated
with emphasis on the effects on blood pressure (BP), heart rate (HR) and carotid artery diameter.
Methods: Characteristics of patients that were operated for CSS in a single institute between 1980-2007 were studied by a
retrospective chart review. Alive and fit patients additionally received a standardized interview investigating symptoms of
residual CSS or baroreflex failure. They underwent a test panel consisting of office BP measurement, carotid sinus
massage (CSM), table tilt testing, 24-hour ECG and ambulatory BP measurement (ABPM) and carotid duplex.
Unoperated, age- and sex- matched individuals without CSS served as controls.
Results: After a total follow up of 91±34 months, 22 of 26 patients (85%) were asymptomatic and 20 of them (77%)
without a pacemaker. Of the 7 surviving and fit patients, six were free of CSS symptoms (follow up 114 ± 81 months).
Recurrence of CSS after an initial successful carotid denervation was not observed. BP level, BP variability and carotid
diameters were not different compared to controls.
Conclusion: Carotid denervation by adventitial stripping of the ICA for CSS seems effective and safe on the long term. A
randomized controlled trial comparing the efficacy and safety of carotid denervation, pacing and medical treatment is
needed for optimal future treatment of patients suffering from CSS.