L-Arginine Catalysed Knoevenagel Condensation: An Unambiguous Synthesis of Cyano-Nitrophenylacetamide, Benzimidazole Acetonitrile & 3-Indole Substituted Alkenes

Author(s): K. Srinivas, Naresh Kumar Katari, P. Satya Karuna, M.S. Surendra Babu

Journal Name: Current Organocatalysis

Volume 2 , Issue 1 , 2015

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Graphical Abstract:


L-Arginine catalyzed Knoevenagel condensation of active methylene compounds, 2-cyano-N-(2- nitrophenyl)acetamide, 2-cyanomethyl benzimidazole, ethylcyanoacetate with benzaldehydes, indole-3- carboxaldehydes under mild and efficient conditions resulting in the formation of respective products. The isolation procedure is quiet easy and products recovered without further purification.

Keywords: 2-cyanomethyl benzimidazole, ethylcyanoacetate, indole-3-carboxaldehydes, knoevenagel reaction, L-arginine, Onitroaniline.

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Article Details

Year: 2015
Published on: 25 February, 2015
Page: [44 - 50]
Pages: 7
DOI: 10.2174/2213337201666141110222400

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