L-Arginine Catalysed Knoevenagel Condensation: An Unambiguous Synthesis of Cyano-Nitrophenylacetamide, Benzimidazole Acetonitrile & 3-Indole Substituted Alkenes

Title:L-Arginine Catalysed Knoevenagel Condensation: An Unambiguous Synthesis of Cyano-Nitrophenylacetamide, Benzimidazole Acetonitrile & 3-Indole Substituted Alkenes

VOLUME: 2 ISSUE: 1

Author(s):K. Srinivas, Naresh Kumar Katari, P. Satya Karuna and M.S. Surendra Babu

Affiliation:Department of Chemistry, GITAM School of Technology, GITAM University, Hyderabad Technological Park campus, Rudraram, Medak (A.P.) - 502 329, India.

Keywords:2-cyanomethyl benzimidazole, ethylcyanoacetate, indole-3-carboxaldehydes, knoevenagel reaction, L-arginine, Onitroaniline.

Abstract:L-Arginine catalyzed Knoevenagel condensation of active methylene compounds, 2-cyano-N-(2- nitrophenyl)acetamide, 2-cyanomethyl benzimidazole, ethylcyanoacetate with benzaldehydes, indole-3- carboxaldehydes under mild and efficient conditions resulting in the formation of respective products. The isolation procedure is quiet easy and products recovered without further purification.

Cite this article as:

K. Srinivas, Naresh Kumar Katari, P. Satya Karuna and M.S. Surendra Babu, “L-Arginine Catalysed Knoevenagel Condensation: An Unambiguous Synthesis of Cyano-Nitrophenylacetamide, Benzimidazole Acetonitrile & 3-Indole Substituted Alkenes”, Current Organocatalysis (2015) 2: 44. https://doi.org/10.2174/2213337201666141110222400

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