Green Synthesis of Phosphoryl-2-Oxo-2H-Pyran via Three Component Reaction of Trialkyl Phosphites

Author(s): Zinatossadat Hossaini, Fatemeh Sheikholeslami-Farahani, Faramarz Rostami-Charati

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 17 , Issue 9 , 2014


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Abstract:

An effective one-pot synthesis of dialkoxyphosphoryl-2-oxo-2H-pyran derivatives by three-component reaction of alky bromides and dialkyl acetylenedicarboxylates in the presence of trialkyl phosphite is described. The reactions were performed under solvent-free conditions at 50°C and neutral conditions and provided good yields of products.

Keywords: 2H-pyran, Alky bromide, dialkyl acetylenedicarboxylates, green chemistry, three-component reaction, trialkyl phosphite.

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Article Details

VOLUME: 17
ISSUE: 9
Year: 2014
Published on: 06 November, 2014
Page: [804 - 807]
Pages: 4
DOI: 10.2174/1386207317666141106155038
Price: $65

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