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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Green Synthesis of Phosphoryl-2-Oxo-2H-Pyran via Three Component Reaction of Trialkyl Phosphites

Author(s): Zinatossadat Hossaini, Fatemeh Sheikholeslami-Farahani and Faramarz Rostami-Charati

Volume 17, Issue 9, 2014

Page: [804 - 807] Pages: 4

DOI: 10.2174/1386207317666141106155038

Price: $65

Abstract

An effective one-pot synthesis of dialkoxyphosphoryl-2-oxo-2H-pyran derivatives by three-component reaction of alky bromides and dialkyl acetylenedicarboxylates in the presence of trialkyl phosphite is described. The reactions were performed under solvent-free conditions at 50°C and neutral conditions and provided good yields of products.

Keywords: 2H-pyran, Alky bromide, dialkyl acetylenedicarboxylates, green chemistry, three-component reaction, trialkyl phosphite.


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