A novel series of coumarin fused benzothiazepines has been synthesized via coupling of oaminothiophenol
with in situ generated 3-benzylidenechroman-2,4-diones. These novel compounds were
screened for their in vitro antioxidant activity against free radical form of ABTS and cytotoxic activity
against U87 human glioma cells. Molecular modeling and QSAR analysis were performed to explore comprehensive
Keywords: Anticancererous, antioxidant, coumarin fused 1, 5-benzothiazepines, reactive oxygen species, structure-activity relationships.
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