Abstract
A novel series of coumarin fused benzothiazepines has been synthesized via coupling of oaminothiophenol with in situ generated 3-benzylidenechroman-2,4-diones. These novel compounds were screened for their in vitro antioxidant activity against free radical form of ABTS and cytotoxic activity against U87 human glioma cells. Molecular modeling and QSAR analysis were performed to explore comprehensive structure-activity relationships.
Keywords: Anticancererous, antioxidant, coumarin fused 1, 5-benzothiazepines, reactive oxygen species, structure-activity relationships.
Mini-Reviews in Organic Chemistry
Title:Synthesis and SARs of Coumarin Fused 1,5-Benzothiazepines as Novel Anticancer and Antioxidant Agents
Volume: 12 Issue: 1
Author(s): Mazaahir Kidwai, Roona Poddar, Arti Jain, Rakesh Kumar and Pratibha M. Luthra
Affiliation:
Keywords: Anticancererous, antioxidant, coumarin fused 1, 5-benzothiazepines, reactive oxygen species, structure-activity relationships.
Abstract: A novel series of coumarin fused benzothiazepines has been synthesized via coupling of oaminothiophenol with in situ generated 3-benzylidenechroman-2,4-diones. These novel compounds were screened for their in vitro antioxidant activity against free radical form of ABTS and cytotoxic activity against U87 human glioma cells. Molecular modeling and QSAR analysis were performed to explore comprehensive structure-activity relationships.
Export Options
About this article
Cite this article as:
Kidwai Mazaahir, Poddar Roona, Jain Arti, Kumar Rakesh and Luthra M. Pratibha, Synthesis and SARs of Coumarin Fused 1,5-Benzothiazepines as Novel Anticancer and Antioxidant Agents, Mini-Reviews in Organic Chemistry 2015; 12 (1) . https://dx.doi.org/10.2174/1570193X11666141029004602
DOI https://dx.doi.org/10.2174/1570193X11666141029004602 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
Call for Papers in Thematic Issues
Navigating the 2D Universe in Organic Chemistry
This special issue explores the transformative impact of two-dimensional (2D) materials on the realm of organic chemistry, unraveling new possibilities for synthesis, functionalization, and applications of organic compounds. Focused on the unique chemistry within this novel dimension, the issue highlights breakthroughs in the field of 2D organic chemistry. Contributions are ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Automated Brain Tumor Segmentation from MRI Images using Morphometric Algorithms
Current Signal Transduction Therapy Molecular Targeting of Cell Death Signal Transduction Pathways in Cancer
Current Signal Transduction Therapy Synthesis, Cytotoxicity and Antimicrobial Activity of New Enmein-type Kauranoid Diterpenoid Derivatives
Anti-Cancer Agents in Medicinal Chemistry Anticancer Potential and Molecular Targets of Pristimerin: A Mini- Review
Current Cancer Drug Targets Resistance to Anti-VEGF Agents
Current Pharmaceutical Design IAPs as a Target for Anticancer Therapy
Current Cancer Drug Targets Comparing the Interaction of Cyclophosphamide Monohydrate to Human Serum Albumin as Opposed to Holo-Transferrin by Spectroscopic and Molecular Modeling Methods: Evidence for Allocating the Binding Site
Protein & Peptide Letters Recent Patents and Patent Applications Relating to mTOR Pathway
Recent Patents on DNA & Gene Sequences Mesenchymal Stem Cells: A New Generation of Therapeutic Agents as Vehicles in Gene Therapy
Current Gene Therapy Dendritic Cell Immunotherapy for Melanoma
Reviews on Recent Clinical Trials siRNA Therapy, Challenges and Underlying Perspectives of Dendrimer as Delivery Vector
Current Pharmaceutical Design Nanomedicines Based Drug Delivery Systems for Anti-Cancer Targeting and Treatment
Current Drug Delivery Overview of Pediatric Epilepsy
Current Pediatric Reviews Phosphonium Salt Displays Cytotoxic Effects Against Human Cancer Cell Lines
Anti-Cancer Agents in Medicinal Chemistry Do Not Say Ever Never More: The Ins and Outs of Antiangiogenic Therapies
Current Pharmaceutical Design NAD Metabolism and Functions: A Common Therapeutic Target for Neoplastic, Metabolic and Neurodegenerative Diseases
Current Topics in Medicinal Chemistry Cyclophilin function in Cancer; lessons from virus replication
Current Molecular Pharmacology Genetic Modification of Natural Killer Cells for Leukemia Therapies
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Beneficial Effects of Herbs, Spices and Medicinal Plants on the Metabolic Syndrome, Brain and Cognitive Function
Central Nervous System Agents in Medicinal Chemistry Redox Environment and its Meaning for Breast Cancer Cells Fate
Current Cancer Drug Targets