Synthesis and SARs of Coumarin Fused 1,5-Benzothiazepines as Novel Anticancer and Antioxidant Agents

Author(s): Mazaahir Kidwai, Roona Poddar, Arti Jain, Rakesh Kumar, Pratibha M. Luthra

Journal Name: Mini-Reviews in Organic Chemistry

Volume 12 , Issue 1 , 2015

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Graphical Abstract:


A novel series of coumarin fused benzothiazepines has been synthesized via coupling of oaminothiophenol with in situ generated 3-benzylidenechroman-2,4-diones. These novel compounds were screened for their in vitro antioxidant activity against free radical form of ABTS and cytotoxic activity against U87 human glioma cells. Molecular modeling and QSAR analysis were performed to explore comprehensive structure-activity relationships.

Keywords: Anticancererous, antioxidant, coumarin fused 1, 5-benzothiazepines, reactive oxygen species, structure-activity relationships.

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Article Details

Year: 2015
Published on: 24 December, 2014
Page: [24 - 33]
Pages: 10
DOI: 10.2174/1570193X11666141029004602

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