Goldberg Reaction: Development, Mechanistic Insights and Applications

Author(s): Anns Maria Thomas, Asha Sujatha, Gopinathan Anilkumar

Journal Name: Mini-Reviews in Organic Chemistry

Volume 12 , Issue 1 , 2015

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Graphical Abstract:


Cu-catalyzed N-arylation of amides commonly known as Goldberg reaction is an important transformation in organic synthesis for the construction of pharmaceuticals and fine chemicals. This is the first review in this area which exclusively deals with recent developments in Goldberg reactions with special focus on mechanistic aspects, catalyst development as well as on the recent applications of this reaction in drug synthesis.

Keywords: amides, arylations, C-N coupling, catalysis, copper, Goldberg reaction.

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Article Details

Year: 2015
Published on: 24 December, 2014
Page: [3 - 23]
Pages: 21
DOI: 10.2174/1570193X11666141029002910

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