Title:Recent Survey on Nanosuspension: A Patent Overview
VOLUME: 9 ISSUE: 1
Author(s):Sahilhusen I. Jethara, Alpesh D. Patel, Mukesh R. Patel and Kanu R. Patel
Affiliation:Department of Pharmaceutics, Shri B. M. Shah College of Pharmaceutical Education and Research, College Campus, Modasa -383315, Gujarat, India.
Keywords:Controlled drug delivery, nanosuspension patent, nanosuspension, routes.
Abstract:The major goals of designing nanosuspension of nanosize materials are increasing due to their tremendous
potential as a drug delivery system with the wide range of applications. Nanosuspension is a unique
tool for improving the bioavailability of poorly soluble drugs. Nanosuspension drug delivery has wide range
of application like oral, injectable, transdermal, inhalation, peroral, ocular, pulmonary and topical etc. by improviing the
bioavailability, reducing the dose, gastric irritation, decreasing intra subject variability and increasing adhesivness with intestinal
membrane. Recently, nanosuspension has been received much interest as a way to resolve solubility and stability
problem because of their cost-effectiveness and technical simplicity compare to other liposome and colloidal drug carriers.
Nanosuspensions are engaged to control particle size, surface properties and release of pharmacologically active
agents in order to achieve the site-specific action of the drug at the therapeutically optimal rate, improve the bioavaibility
of drug with poor solubility and dose regimen. Application and preparation method of nanosuspension has been reported
by research articles and patented in different countries. Most of the marketed nanosuspensions are in preclinical and clinical
based study for its application. More than 100 patents have been published on nanosuspensions by the recent days.
This patent reviews covers different methods of pharmaceutical preparation and applications in drug delivery as well as
the recent marketed published or granted patent surveys. This patent review is useful in enhance the knowledge of controlled
drug delivery and applications.
