Recently, great attention has been paid to in situ gel-forming chitosan/glycerophosphate
(CS/Gp) formulation due to its high biocompatibility with incorporated cells and medical agents, biodegradability
and sharp thermosensitive gelation. CS/Gp is in liquid state at room temperature and after
minimally invasive administration into the desired tissue, it forms a solid-like gel as a response to
temperature increase. The overview of various recently patented strategies on injectable delivery systems indicates the
significance of this formulation in biomedical applications. This thermosensitive hydrogel has a great potential as scaffold
material in tissue engineering, due to its good biocompatibility, minimal immune reaction, high antibacterial nature, good
adhesion to cells and the ability to be molded in various geometries. Moreover, CS/Gp hydrogel has been utilized as a
smart drug delivery system to increase patient compliance by maintaining the drug level in the therapeutic window for a
long time while avoiding the need for frequent injections of the therapeutic agent. This review paper highlights the recent
patents and investigations on different formulations of CS/Gp hydrogels as tissue engineering scaffolds and carriers for
therapeutic agents. Additionally, the dominant mechanism of sol-gel transition in those systems as well as their physicochemical
properties and biocompatibility are discussed in detail.
Keywords: Chitosan, drug delivery, glycerophosphate, hydrogel, injectable, thermosensitive, tissue engineering.
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