A Tandem and Domino Protocol for Synthesis of Chromeno-, Pyrano- and Quinolinofused Spiro[pyrazolo[3,4-b]pyridine-indolines]

Author(s): Sunil K. Gupta, Anand K. Arya, Sarita Khandelwal, Mahendra Kumar

Journal Name: Current Organic Chemistry

Volume 18 , Issue 19 , 2014

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Graphical Abstract:


An efficient tandem and domino protocol for the synthesis of chromeno-, pyrano-, and quinolino- fused spiro[pyrazolo[3,4- b]pyridine-indolines] has been developed. The present method involves one-pot pseudo five-component reaction of hydrazine hydrate and ethyl acetoacetate with isatin, malonitrile/ cyclic β-diketones and ammonium acetate/ primary aromatic amines in ethanol without using catalyst.

Keywords: Multicomponent domino reaction, spirooxindole, pyrazolo[3, 4-b]pyridine, pyrazolochromenopyridine, pyrazolopyranopyridine, pyrazoloquinolinopyridine.

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Article Details

Year: 2014
Published on: 27 October, 2014
Page: [2555 - 2560]
Pages: 6
DOI: 10.2174/138527281819141028114753
Price: $58

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