A Comprehensive Review on Combretastatin Analogues as Tubulin Binding Agents

Author(s): Rupinder K. Gill, Ramandeep Kaur, Gurneet Kaur, Ravindra K. Rawal, Anamik K. Shah, Jitender Bariwal

Journal Name: Current Organic Chemistry

Volume 18 , Issue 19 , 2014

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Graphical Abstract:


Tubulin represents a potent target in cancer chemotherapy. Combretastatin is a naturally occurring well known tubulin polymerization inhibitor. Combretastatin and its analogues have been discussed in this review in detail. For better understanding, this review is subdivided as per the carbon distance between to the two aromatic rings. Under these heading, various synthetic analogues, general synthetic route, their brief SAR and structures of the most potent compound has been discussed. This article will be a good platform to guide the chemist to design and synthesize drug like molecules for tubulin polymerization inhibitory potential with optimized pharmacokinetic profile.

Keywords: Anticancer, antiproliferative, combretastatin analogues, combretastatin, microtubule binding agents, tubulin binding agents.

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Article Details

Year: 2014
Page: [2462 - 2512]
Pages: 51
DOI: 10.2174/138527281819141028114428
Price: $58

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