Continuing our research programme to develop the synthesis of small heterocyclic entities, in the present study we prepared
carbohydrazides of privileged coumarins through highly attractive Meerwein arylation. The reaction condition is compatible with a wide
variety of functional groups present on coumarin and aniline, delivered in moderate to good yields of the target scaffolds. The heterocyclic
hydrazide skeletons are challenging to synthesize and have tremendous applications in the drug discovery area. The resulting structural
diversity was screened for its antitubercular activity utilizing Mtb H37Rv strains via the MABA assay method. The growth inhibition
of the designed diversity was found to be in the range 50–97%. Several molecules were found to be promising for further chemical development
and in silico analysis.
Keywords: Coumarin, carbo-hydrazides, Mtb, H37Rv, MABA.
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