Title:Personalized and Participatory Medicine as a Future Tool to Combat Cardiovascular Disease in Developing Countries
VOLUME: 12 ISSUE: 3
Author(s):Pinar Kuru and Mehmet Agirbasli
Affiliation:Marmara University, School of Medicine, Department of Cardiology, 3th floor, Fevzi Cakmak Mah., Mimar Sinan Cad., No: 41, 34899, Ust Kaynarca, Pendik, Istanbul, Turkey.
Keywords:Antiplatelet, antithrombotic theraphy, aspirin, cardiovascular therapeutics, clopidogrel, personalized medicine,
pharmacogenomics.
Abstract:Cardiovascular disease is one of the main leading causes of mortality. Approximately, 80%
of cardiovascular deaths occur in low- and middle-income countries (LMICs). Current guidelines
which are based on randomized controlled trials direct the cardiovascular diagnosis and treatment.
Yet, such guidelines do not benefit every patient. Recent studies question the ‘one size fits all’ principle
particularly in complex traits such as thrombosis. The cost and duration of genetic testing continue to
decline rapidly and novel strategies are on the rise to determine individual susceptibility to diseases
and responses to therapy. Multidimensional evaluation of the patient with his/her environment,
genomics, detailed medical history, and compliance to treatment are crucial in preventing complications from antithrombotic
treatment. In this review, we discuss some of the pharmacogenomic features of antithrombotic medications that are
currently used. We believe current personalized medicine and pharmacogenomics are pivotal in elucidating contradictory
results of randomized controlled trials to test the same antithrombotic regimen on all participants.
