A series of di-substituted cinnamic hydroxamic derivatives was designed, synthesized and
evaluated as HDAC inhibitors. Compound 5f (HS270) demonstrated potent HDAC inhibitory and antiproliferative
activities. In xenograft model, 5f showed significant antitumor efficacy in tumorbearing
Keywords: Antitumor, cinnamic, design, histone deacetylase, HDAC, hydroxamaic acid.
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