The Cell-Type Specificity and Endosomal Escape of Cell-Penetrating Peptides

Author(s): Jing Feng, Liling Tang

Journal Name: Current Pharmaceutical Design

Volume 21 , Issue 10 , 2015

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Cell-penetrating peptides (CPPs) have become a great potential non-invasive carrier candidate for the delivery of various cell-impermeable therapeutic cargoes such as proteins, polypeptides and nucleic acid. However, the lack of tissue specificity and entrapment in the endocytic vesicles is the primary limitation to the application of these peptides in cargo delivery. Emphasis should be placed on developing novel methods to overcome these barriers. In this review, several current strategies to promote tissue specificity and endosomal escape of CPPs will be described, as well as the comparison of different approaches in efficacy and security. Finally, this review will be attributed to new ideas to improve the tissue specificity and cytosolic availability of CPP-cargoes.

Keywords: CPPs, cell-type specificity, endosomal escape.

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Article Details

Year: 2015
Page: [1351 - 1356]
Pages: 6
DOI: 10.2174/1381612820666141023155017
Price: $65

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PDF: 68