Abstract
Cell-penetrating peptides (CPPs) have become a great potential non-invasive carrier candidate for the delivery of various cell-impermeable therapeutic cargoes such as proteins, polypeptides and nucleic acid. However, the lack of tissue specificity and entrapment in the endocytic vesicles is the primary limitation to the application of these peptides in cargo delivery. Emphasis should be placed on developing novel methods to overcome these barriers. In this review, several current strategies to promote tissue specificity and endosomal escape of CPPs will be described, as well as the comparison of different approaches in efficacy and security. Finally, this review will be attributed to new ideas to improve the tissue specificity and cytosolic availability of CPP-cargoes.
Keywords: CPPs, cell-type specificity, endosomal escape.
Current Pharmaceutical Design
Title:The Cell-Type Specificity and Endosomal Escape of Cell-Penetrating Peptides
Volume: 21 Issue: 10
Author(s): Jing Feng and Liling Tang
Affiliation:
Keywords: CPPs, cell-type specificity, endosomal escape.
Abstract: Cell-penetrating peptides (CPPs) have become a great potential non-invasive carrier candidate for the delivery of various cell-impermeable therapeutic cargoes such as proteins, polypeptides and nucleic acid. However, the lack of tissue specificity and entrapment in the endocytic vesicles is the primary limitation to the application of these peptides in cargo delivery. Emphasis should be placed on developing novel methods to overcome these barriers. In this review, several current strategies to promote tissue specificity and endosomal escape of CPPs will be described, as well as the comparison of different approaches in efficacy and security. Finally, this review will be attributed to new ideas to improve the tissue specificity and cytosolic availability of CPP-cargoes.
Export Options
About this article
Cite this article as:
Feng Jing and Tang Liling, The Cell-Type Specificity and Endosomal Escape of Cell-Penetrating Peptides, Current Pharmaceutical Design 2015; 21 (10) . https://dx.doi.org/10.2174/1381612820666141023155017
DOI https://dx.doi.org/10.2174/1381612820666141023155017 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Cancer and Aids: New Trends in Drug Design and Chemotherapy
Current Computer-Aided Drug Design Hybrid Pharmacophore Design and Synthesis of Naphthalimide– Benzimidazole Conjugates as Potential Anticancer Agents
Letters in Drug Design & Discovery Ceramidases in Hematological Malignancies: Senseless or Neglected Target?
Anti-Cancer Agents in Medicinal Chemistry MiRNAs in Human Cancers: The Diagnostic and Therapeutic Implications
Current Pharmaceutical Design Specificity of Binding in Protein Kinases
Current Enzyme Inhibition Gene Expression Profiling in Rodent Models for Schizophrenia
Current Neuropharmacology γ δ T Cell Modulation in Anticancer Treatment
Current Cancer Drug Targets Editorial Review of 2012
Current Radiopharmaceuticals CDK-associated Cullin 1 Promotes Cell Proliferation and Inhibits Cell Apoptosis in Human Glioblastoma
Current Cancer Drug Targets Matrix Metalloproteinases as Potential Targets in the Venous Dilation Associated with Varicose Veins
Current Drug Targets Implications of FLT3 Mutations in the Therapy of Acute Myeloid Leukemia
Reviews on Recent Clinical Trials Small Molecule Toxins Targeting Tumor Receptors
Current Pharmaceutical Design Monitoring Therapy with Gene Expression Profiling Reveals Physiological Differences in Drug Action
Current Pharmaceutical Design Cannabinoid Type 2 Receptor as a Target for Chronic - Pain
Mini-Reviews in Medicinal Chemistry The Novel Role for Lyn in Integrin Signaling in Human Disease
Current Signal Transduction Therapy New N’-Arylidene-2-[(4-Nitrophenyl)Piperazın-1-yl]Acetohydrazide Derivatives: Synthesis and Anticancer Activity Investigation
Letters in Drug Design & Discovery Characterization of the Early CNS Stress Biomarkers and Profiles Associated with Neuropsychiatric Diseases
Current Genomics Thiopurine S-Methyltransferase as a Pharmacogenetic Biomarker: Significance of Testing and Review of Major Methods
Cardiovascular & Hematological Agents in Medicinal Chemistry Chemoradiotherapy of Human Tumors: Novel Approaches from Nanomedicine
Current Pharmaceutical Design The Potential Therapeutic Use of Stem Cells in Cartilage Repair
Current Stem Cell Research & Therapy