Applications of Barton-McCombie Reaction in Total Syntheses

Author(s): Majid M. Heravi, Atefe Bakhtiari, Zeinab Faghihi

Journal Name: Current Organic Synthesis

Volume 11 , Issue 6 , 2014

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Graphical Abstract:


The Barton-McCombie reaction (B-M reaction) is deoxygenation of aliphatic alcohols via thioacylation followed by a radical cleavage. Variations of the reactions may utilize different thioacyl fragments and hydrogen sources. In this review article, however, we have focused on the applications of this reaction as a mild and functional group tolerant method in deoxygenation step in total syntheses of some well recognized natural products.

Keywords: Barton-McCombie reaction, deoxygenation, free-radical reaction, hydroxyl group, natural product, tin hydrid, total syntheses, xanthate.

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Article Details

Year: 2014
Page: [787 - 823]
Pages: 37
DOI: 10.2174/157017941106141023113539
Price: $65

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