Optimisation of [11C]Raclopride Production Using a Synthra GPextent System

Author(s): Gary Perkins, Rajeev Sheth, Ivan Greguric, Giancarlo Pascali

Journal Name: Current Radiopharmaceuticals

Volume 7 , Issue 2 , 2014

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Abstract:

The dopamine D2 receptor radiotracer [11C]Raclopride is used extensively in clinical and preclinical imaging. Currently, a wide range of methods to produce [11C]Raclopride have been developed using traditional vessel reactions as well as cartridge or captive solvent.

This work reports the optimisation of the production of [11C]Raclopride using a Synthra GPextent, comparing various methods. With optimised conditions, we were able to obtain 4±2% (ndc) yield of [11C]Raclopride (100 GBq [11C]CO2, n = 42) in 25 min. The radiochemical purity was >95% with specific activities of 135±41 MBq/nmol at end of synthesis.

Keywords: 11Carbon, GPextent, optimization, raclopride.

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Article Details

VOLUME: 7
ISSUE: 2
Year: 2014
Page: [100 - 106]
Pages: 7
DOI: 10.2174/1874471007666141021111635
Price: $65

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