Title:MicroRNA-34 Family, Mechanisms of Action in Cancer: A Review
VOLUME: 14 ISSUE: 8
Author(s):Hamidreza Maroof, Ali Salajegheh, Robert A. Smith and Alfred K.-Y. Lam
Affiliation:Head of Pathology, Griffith Medical School, Gold Coast Campus, Gold Coast QLD 4222, Australia.
Keywords:Cancer, carcinoma, miR-34a, miR-34b, miR-34c, tumour suppressor gene, miRNA-34 family.
Abstract:Altered expression of the microRNA-34 family has been determined to be involved in the pathogenesis of
many cancers. In this review, the current knowledge of the cancer-related mechanisms in relation to the modulatory
effects of microRNA-34 family were analysed. Expression analysis of the microRNA-34 family has suggested that its
members play significant roles in many aspects of cancer biology including proliferation, invasion/metastasis,
apoptosis/cell survival, cell cycle/cell growth, migration, senescence/aging, angiogenesis, epigenetic silencing and
methylation by regulation of the expression of their target genes. Thus, microRNA-34 family members could act as
prognostic markers and therapeutic targets in human cancers.
