MicroRNA-34 Family, Mechanisms of Action in Cancer: A Review

Author(s): Hamidreza Maroof, Ali Salajegheh, Robert A. Smith, Alfred K.-Y. Lam

Journal Name: Current Cancer Drug Targets

Volume 14 , Issue 8 , 2014

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Graphical Abstract:


Altered expression of the microRNA-34 family has been determined to be involved in the pathogenesis of many cancers. In this review, the current knowledge of the cancer-related mechanisms in relation to the modulatory effects of microRNA-34 family were analysed. Expression analysis of the microRNA-34 family has suggested that its members play significant roles in many aspects of cancer biology including proliferation, invasion/metastasis, apoptosis/cell survival, cell cycle/cell growth, migration, senescence/aging, angiogenesis, epigenetic silencing and methylation by regulation of the expression of their target genes. Thus, microRNA-34 family members could act as prognostic markers and therapeutic targets in human cancers.

Keywords: Cancer, carcinoma, miR-34a, miR-34b, miR-34c, tumour suppressor gene, miRNA-34 family.

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Article Details

Year: 2014
Published on: 24 November, 2014
Page: [737 - 751]
Pages: 15
DOI: 10.2174/1568009614666141020100337
Price: $65

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