Abstract
Altered expression of the microRNA-34 family has been determined to be involved in the pathogenesis of many cancers. In this review, the current knowledge of the cancer-related mechanisms in relation to the modulatory effects of microRNA-34 family were analysed. Expression analysis of the microRNA-34 family has suggested that its members play significant roles in many aspects of cancer biology including proliferation, invasion/metastasis, apoptosis/cell survival, cell cycle/cell growth, migration, senescence/aging, angiogenesis, epigenetic silencing and methylation by regulation of the expression of their target genes. Thus, microRNA-34 family members could act as prognostic markers and therapeutic targets in human cancers.
Keywords: Cancer, carcinoma, miR-34a, miR-34b, miR-34c, tumour suppressor gene, miRNA-34 family.
Current Cancer Drug Targets
Title:MicroRNA-34 Family, Mechanisms of Action in Cancer: A Review
Volume: 14 Issue: 8
Author(s): Hamidreza Maroof, Ali Salajegheh, Robert A. Smith and Alfred K.-Y. Lam
Affiliation:
Keywords: Cancer, carcinoma, miR-34a, miR-34b, miR-34c, tumour suppressor gene, miRNA-34 family.
Abstract: Altered expression of the microRNA-34 family has been determined to be involved in the pathogenesis of many cancers. In this review, the current knowledge of the cancer-related mechanisms in relation to the modulatory effects of microRNA-34 family were analysed. Expression analysis of the microRNA-34 family has suggested that its members play significant roles in many aspects of cancer biology including proliferation, invasion/metastasis, apoptosis/cell survival, cell cycle/cell growth, migration, senescence/aging, angiogenesis, epigenetic silencing and methylation by regulation of the expression of their target genes. Thus, microRNA-34 family members could act as prognostic markers and therapeutic targets in human cancers.
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Cite this article as:
Maroof Hamidreza, Salajegheh Ali, A. Smith Robert and K.-Y. Lam Alfred, MicroRNA-34 Family, Mechanisms of Action in Cancer: A Review, Current Cancer Drug Targets 2014; 14 (8) . https://dx.doi.org/10.2174/1568009614666141020100337
DOI https://dx.doi.org/10.2174/1568009614666141020100337 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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