Theories and Treatment of Drug Dependency: A Neurochemical Perspective

Author(s): Sheila Pakdaman, Richard E. Wilcox, Joseph D. Miller

Journal Name: Current Molecular Pharmacology

Volume 7 , Issue 1 , 2014

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Treatment of chemical dependence (“addiction”) requires an understanding of its effects on the brain. To guide research in the area of chemical dependence, several foundational theories have been developed. These include the incentive salience, receptor down-regulation, opponent process, and psychomotor stimulant theories. These have been important both in summarizing and in guiding investigations. However, the extant theories do not provide a single unified framework nor have they yielded all of the guidance necessary for effective chemical dependence treatment. The present paper summarizes and then integrates these theories and suggests some implications for the treatment followed by this integration.

Keywords: Behavioral sensitization, dopamine, like want need, medial prefrontal cortex, receptor down-regulation, ventral striatum.

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Article Details

Year: 2014
Published on: 05 January, 2015
Page: [52 - 66]
Pages: 15
DOI: 10.2174/1874467207666141017150625

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