Abstract
Treatment of chemical dependence (“addiction”) requires an understanding of its effects on the brain. To guide research in the area of chemical dependence, several foundational theories have been developed. These include the incentive salience, receptor down-regulation, opponent process, and psychomotor stimulant theories. These have been important both in summarizing and in guiding investigations. However, the extant theories do not provide a single unified framework nor have they yielded all of the guidance necessary for effective chemical dependence treatment. The present paper summarizes and then integrates these theories and suggests some implications for the treatment followed by this integration.
Keywords: Behavioral sensitization, dopamine, like want need, medial prefrontal cortex, receptor down-regulation, ventral striatum.
Current Molecular Pharmacology
Title:Theories and Treatment of Drug Dependency: A Neurochemical Perspective
Volume: 7
Author(s): Sheila Pakdaman, Richard E. Wilcox and Joseph D. Miller
Affiliation:
Keywords: Behavioral sensitization, dopamine, like want need, medial prefrontal cortex, receptor down-regulation, ventral striatum.
Abstract: Treatment of chemical dependence (“addiction”) requires an understanding of its effects on the brain. To guide research in the area of chemical dependence, several foundational theories have been developed. These include the incentive salience, receptor down-regulation, opponent process, and psychomotor stimulant theories. These have been important both in summarizing and in guiding investigations. However, the extant theories do not provide a single unified framework nor have they yielded all of the guidance necessary for effective chemical dependence treatment. The present paper summarizes and then integrates these theories and suggests some implications for the treatment followed by this integration.
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Cite this article as:
Pakdaman Sheila, Wilcox E. Richard and Miller D. Joseph, Theories and Treatment of Drug Dependency: A Neurochemical Perspective, Current Molecular Pharmacology 2014; 7 (1) . https://dx.doi.org/10.2174/1874467207666141017150625
DOI https://dx.doi.org/10.2174/1874467207666141017150625 |
Print ISSN 1874-4672 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-4702 |
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