Ketoheptoses are rarely found in Nature, yet early on D-manno-heptulose could be isolated from Avocado. Following
detection of D-manno-heptulose to act as an inhibitor of glucokinase the involvement of ketoheptoses in biomedical
applications required synthetic approaches. This review focuses on syntheses of ketoheptoses by rearrangement reactions
(de Bruyn-van Ekenstein, Amadori, Bilik) as well as chain elongation reactions (Henry, Grignard, exocyclic enolethers)
and gives an overview of the synthetic activity from early syntheses to most recent improvements.
Keywords: 2-ketoheptoses, chain elongation reactions, D-manno-heptulose, fluoro-deoxy-and amino-deoxy derivatives,
non-invasive imaging, rearrangement reactions, synthesis of ketoheptoses, β-cells.
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