Proteinase Inhibitors: A Promising Drug Class for Treating Leishmaniasis

Author(s): Bernardo Acacio Santini Pereira, Franklin Souza-Silva, Mariana Silva-Almeida, Raquel Santos-de-Souza, Luiz Filipe Goncalves de Oliveira, Michelle Lopes Ribeiro-Guimaraes, Carlos Roberto Alves

Journal Name: Current Drug Targets

Volume 15 , Issue 12 , 2014

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This review presents and discusses the current status and perspectives of leishmaniasis treatment, with a special focus on the use of proteinase inhibitors. The history of treatment development, the first- and second-choice modern drugs and the advantages and disadvantages of using proteinases inhibitors as leishmanicidal treatments are presented and discussed. The reports gathered herein confirm the potential usefulness of proteinases inhibitors as an alternative or complement to the current leishmaniasis treatments. They also support the hypothesis that a combined treatment with multiple proteinase inhibitors may be efficient against Leishmania infections in vertebrate hosts.

Keywords: Leishmaniasis, Leishmania, proteinases, proteinase inhibitors, treatment, virulence factors.

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Article Details

Year: 2014
Page: [1121 - 1131]
Pages: 11
DOI: 10.2174/1389450115666141016150007
Price: $65

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PDF: 30