A Simple, Efficient and Environmentally Benign Synthetic Protocol for the Synthesis of Spirooxindoles Using Choline Chloride-Oxalic Acid Eutectic Mixture as Catalyst/Solvent System

Title:A Simple, Efficient and Environmentally Benign Synthetic Protocol for the Synthesis of Spirooxindoles Using Choline Chloride-Oxalic Acid Eutectic Mixture as Catalyst/Solvent System

Volume: 17 Issue: 9

Author(s): Sarita Khandelwal, Anshu Rajawat, Yogesh Kumar Tailor and Mahendra Kumar

Affiliation:

Keywords: Deep eutectic solvent (DES), diversity oriented synthesis, HBD (hydrogen bond donor), medicinally privileged heterocycles, spirooxindoles.

Abstract: An efficient and environmentally benign domino protocol has been presented for the synthesis of structurally diverse spirooxindoles spiroannulated with pyranopyridopyrimidines, indenopyridopyrimidines, and chromenopyridopyrimidines involving three-component reaction of aminouracils, isatins and cyclic carbonyl compounds in deep eutectic solvent (choline chloride-oxalic acid: 1:1) which acts as efficient catalyst and environmentally benign reaction medium. The present protocol offers several advantages such as operational simplicity with easy workup, shorter reaction times excellent yields with superior atom economy and environmentally benign reaction conditions with the use of costeffective, recyclable, non-toxic and bio-degradable DES as catalyst/solvent.

Cite this article as:

Khandelwal Sarita, Rajawat Anshu, Tailor Kumar Yogesh and Kumar Mahendra, A Simple, Efficient and Environmentally Benign Synthetic Protocol for the Synthesis of Spirooxindoles Using Choline Chloride-Oxalic Acid Eutectic Mixture as Catalyst/Solvent System, Combinatorial Chemistry & High Throughput Screening 2014; 17 (9) . https://dx.doi.org/10.2174/1386207317666141016125218