Title:Extraction, Characterization and Evaluation of Film Forming Capacity of Natural Polymer
VOLUME: 4 ISSUE: 3
Author(s):Shubham Verma, Rishabha Malviya and Pramod K. Sharma
Affiliation:Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, G.B. Nagar. U.P. India.
Keywords:Buccal films, extraction, glimepiride, methi, natural polymer, saliva.
Abstract:Nowadays natural or herbal products are more often used in comparison to synthetic products because of their
low toxicity, biodegradability, biocompatibility and cheaper cost. An effort has been made to design and characterize buccal
films of glimepiride using natural polymer. The natural polymer was extracted from Trigonella foenumgraecum
L(Methi) seed. The polymer was extracted by solvent extraction method and was characterized for different parameters
i.e., physical characteristics, bulk density, tapped density, Carr’s index, swelling index, pH and angle of repose. Solubility
behavior of the isolated mucilage, with different solvents, was also studied. It was found that mucilage was insoluble in
cold water but soluble in hot water. The buccal films were formulated using solvent casting technique. The main polymer
used was Methi polymer. Different concentrations of polymer were used in the development of buccal film. The formulated
films were evaluated for different parameters i.e., surface pH, weight uniformity, tensile strength, disintegration,
swelling index, in vitro drug release, drug content, thickness and folding endurance. pH of the formulated films was between
6.8 and 7.4. The drug content of films was in the range of 7.3-9.3. In vitro drug release study showed an average
85% drug release from all the formulated films upto 6 hrs. Swelling index of the formulated films showed good swelling
upto 2 hrs. It was showed that Formulation F3 was the best formulation among all the formulations. In the optimized
batch, the polymer concentration was 300 mg/25 ml.
