Functional heterogeneity of dendritic cells (DCs) observed in atherosclerosis suggest for their complex and multifaced role in
the pathogenesis of atherosclerotic disease. A delicate balance between anti-inflammatory and pro-inflammatory mechanisms drives
atherogenesis, and local microenvironment triggers the actual involvement of DCs in atherosclerosis-associated inflammation. Responding
to microenvironment stimuli, DCs contribute to atherogenesis in both ways being involved in supporting proatherogenic vascular inflammation
and by suppressing inflammatory responses via induction of self-tolerogenic properties and regulatory T cells (Tregs). The
local microenvironment and extrinsic stimuli influence DC phenotype and hence could control the phenotypic switch toward inflammation
Keywords: Atherosclerosis, arteriosclerosis, arteries, inflammation, dendritic cells, plasmacytoid dendritic cells.
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