Immunopathology plays important roles in the development of different life-threatening diseases, such as atherosclerosis and
its consequences (acute myocardial infarction and stroke), cancer, chronic inflammatory diseases. Effective modulation of the immune
system may significantly increase the efficacy of prevention and therapy efforts. Currently there are no marketed drugs capable of normalizing
immune system function in an intrinsic and comprehensive way. Here, we describe a test system designed for complex analysis
of monocyte activity in individuals to diagnose immunopathology and monitor treatment efficacy. This cell-based test system may also
be useful for screening compounds with an immune-correcting effects. Both diagnostic and screening systems are based on primary culture
of human monocytes and/or monocyte-derived macrophages. This is the first step in creating a method for assessment of macrophage
activity, which is required for further development of immune-correcting drugs. The existing preliminary data provide the basis for realization
of this idea.
Keywords: Activation, atherosclerosis, chemokine, cytokine, diagnostics, immunopathology, macrophage, therapy.
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