Growing experimental evidences suggest that dimerization and oligomerization are important for G Protein-
Coupled Receptors (GPCRs) function. The detailed structural information of dimeric/oligomeric GPCRs would be very
important to understand their function. Although it is encouraging that recently several experimental GPCR structures in
oligomeric forms have appeared, experimental determination of GPCR structures in oligomeric forms is still a big challenge,
especially in mimicking the membrane environment. Therefore, development of computational approaches to predict
dimerization of GPCRs will be highly valuable. In this review, we summarize computational approaches that have
been developed and used for modeling of GPCR dimerization. In addition, we introduce a novel two-dimensional
Brownian Dynamics based protein docking approach, which we have recently adapted, for GPCR dimer prediction.
Keywords: Brownian dynamics simulations, coarse grained MD simulations, computer modeling, molecular dynamics simulations,
membrane protein dimerization, protein docking.
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