Title:Recent Advances in Design of Potential Quinoxaline Anti-Infectives
VOLUME: 21 ISSUE: 38
Author(s):Josef Jampilek
Affiliation:Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3, 61242 Brno, Czech Republic.
Keywords:Antibacterials, antifungals, antimycobacterial agents, antiprotozoals, quinoxalines, synthesis.
Abstract:Antimicrobial diazanaphthalenes are indispensable in the treatment of various infections. The quinoxaline scaffold
possesses unique physicochemical properties and provides a possibility of a great number of targeted modifications.
Quinoxaline-based compounds have a wide range of promising biological properties; therefore a special attention is paid
to them for research and designing of new drugs. In fact, quinoxaline can be considered as a privileged structure. The
scaffold can be easily and rapidly constructed, which emphasizes the significance of this favourable structure. The review
is focused on recently reported potential antibacterial, antimycobacterial, antifungal and antiprotozoal agents derived from
the quinoxaline scaffold, their mechanism of action and structure-activity relationships. A brief classification of synthetic
pathways of quinoxaline derivatives is provided too.
