Title:NMR in the Design of Antibacterials
VOLUME: 21 ISSUE: 38
Author(s):Emilija Arsovska, Gregor Mali, Simona Golic Grdadolnik and Anamarija Zega
Affiliation:Faculty of Pharmacy, University of Ljubljana, 1000 Ljubljana, Slovenia.
Keywords:Antibiotics, drug discovery, fragment based drug design, ligand-observed screening, NMR spectroscopy, solid state
NMR, target-observed screening.
Abstract:One of the most challenging areas in drug design is the area of new antibacterial drugs. Despite significant progress
in target validation and screening programs, discovery of new antibacterial classes is not keeping pace with the
growing threat of bacterial resistance. In this review we describe examples of the use of NMR spectroscopy methods in
different phases of antibacterial drug design. First, several frequently used liquid and solid-state NMR techniques are presented,
followed by a review and discussion of the application of NMR spectroscopy to the discovery of new antibacterial
agents.
