The synthesis of risedronic acid and alendronate from 3-pyridylacetic acid and γ-
aminobutyric acid, respectively, using phosphorus oxychloride and phosphorous acid as the
P-reagents and methanesulfonic acid as the solvent was optimized, and the role of
phosphorus oxychloride and phosphorous acid in the reaction was clarified.
Keywords: Alendronate, mechanism, optimization, phosphorus oxychloride, phosphorous acid, risedronic acid, synthesis.
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