Abstract
In the last twenty years the rapid advances in neurogenetic have revolutionized not only the molecular, pathological, inheritance but also the clinical concept of ALS.
Here we review the current genetic breakthrough in familial and sporadic ALS, considering how this knowledge has allowed widening of the scenario on the possible pathogenic disease mechanisms and better understanding of the relationship between the genetic, pathological and clinical subtypes.
Keywords: Amyotrophic Lateral Sclerosis, dementia, genetic tests, GWA, mutation, phenotype, WES.
Current Molecular Medicine
Title:Amyotrophic Lateral Sclerosis: A Genetic Point of View
Volume: 14 Issue: 8
Author(s): C. Carlesi, E. Caldarazzo Ienco, M. Mancuso and G. Siciliano
Affiliation:
Keywords: Amyotrophic Lateral Sclerosis, dementia, genetic tests, GWA, mutation, phenotype, WES.
Abstract: In the last twenty years the rapid advances in neurogenetic have revolutionized not only the molecular, pathological, inheritance but also the clinical concept of ALS.
Here we review the current genetic breakthrough in familial and sporadic ALS, considering how this knowledge has allowed widening of the scenario on the possible pathogenic disease mechanisms and better understanding of the relationship between the genetic, pathological and clinical subtypes.
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Cite this article as:
Carlesi C., Ienco Caldarazzo E., Mancuso M. and Siciliano G., Amyotrophic Lateral Sclerosis: A Genetic Point of View, Current Molecular Medicine 2014; 14 (8) . https://dx.doi.org/10.2174/1566524014666141010155822
DOI https://dx.doi.org/10.2174/1566524014666141010155822 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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