Bridging Over the Troubled Heterogeneity of SPG-Related Pathologies: Mechanisms Unite What Genetics Divide

Author(s): A. Tessa, P.S. Denora, L. Racis, E. Storti, A. Orlacchio, F.M. Santorelli

Journal Name: Current Molecular Medicine

Volume 14 , Issue 8 , 2014

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Abstract:

The hereditary spastic paraplegias (HSP) are characterized by spastic gait with weakness in the legs and additional neurological or extra-neurological signs in "complicated" forms.

The past two decades have witnessed major advances in our understanding of their molecular bases with the identification of a plethora of loci and the cloning of several SPG genes. Combined genetic and clinical information has permitted a modern, molecularly-driven classification and an improved diagnosis, with several new data on the possible disease mechanisms. Further heterogeneity will rapidly emerge with the diffusion of next-generation sequencing platforms and, under the shadow of common themes in the pathogenesis, new therapeutic options will likely emerge for a great number of patients.

Keywords: Hereditary spastic paraplegia, genetic, genotype/phenotype correlations, heterogeneity, mechanisms of disease, mutation, SPG.

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Article Details

VOLUME: 14
ISSUE: 8
Year: 2014
Page: [1034 - 1042]
Pages: 9
DOI: 10.2174/1566524014666141010154526
Price: $65

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