Enantioselective Desymmetrizations Promoted by Bifunctional Organocatalysts

Author(s): Arianna Quintavalla, Lucia Cerisoli, Elisa Montroni

Journal Name: Current Organocatalysis

Volume 1 , Issue 2 , 2014

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Graphical Abstract:


The enantioselective desymmetrization is regarded as an effective strategy for producing chiral compounds from achiral substrates. The past decade saw the establishment of organocatalysis in organic synthesis and also organocatalytic desymmetrizations have emerged in recent years. In particular, bifunctional organocatalysts have shown the ability to promote enantioselective desymmetrizations enabling simultaneous covalent and/or non-covalent activations of the reagents. Many classes of prochiral and meso compounds were efficiently desymmetrized, being cyclic anhydrides ringopening and diols acylation the most widely employed transformations. The goal of this review is to give a comprehensive overview on the developed strategies in the field of the enantioselective desymmetrizations promoted by bifunctional organocatalysts.

Keywords: Bifunctional activation, desymmetrization, enantioselectivity, meso compound, organocatalysis, prochiral substrate.

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Article Details

Year: 2014
Published on: 28 October, 2014
Page: [107 - 171]
Pages: 65
DOI: 10.2174/2213337201666141003222456

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