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Current Organocatalysis

Editor-in-Chief

ISSN (Print): 2213-3372
ISSN (Online): 2213-3380

Enantioselective Desymmetrizations Promoted by Bifunctional Organocatalysts

Author(s): Arianna Quintavalla, Lucia Cerisoli and Elisa Montroni

Volume 1, Issue 2, 2014

Page: [107 - 171] Pages: 65

DOI: 10.2174/2213337201666141003222456

Abstract

The enantioselective desymmetrization is regarded as an effective strategy for producing chiral compounds from achiral substrates. The past decade saw the establishment of organocatalysis in organic synthesis and also organocatalytic desymmetrizations have emerged in recent years. In particular, bifunctional organocatalysts have shown the ability to promote enantioselective desymmetrizations enabling simultaneous covalent and/or non-covalent activations of the reagents. Many classes of prochiral and meso compounds were efficiently desymmetrized, being cyclic anhydrides ringopening and diols acylation the most widely employed transformations. The goal of this review is to give a comprehensive overview on the developed strategies in the field of the enantioselective desymmetrizations promoted by bifunctional organocatalysts.

Keywords: Bifunctional activation, desymmetrization, enantioselectivity, meso compound, organocatalysis, prochiral substrate.

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