Antiangiogenic Agents in the Treatment of HER2-Negative Metastatic breast Cancer: A Brief Review

Author(s): Nabil Ismaili

Journal Name: Current Angiogenesis (Discontinued)

Volume 3 , Issue 2 , 2014

Graphical Abstract:


Angiogenesis is an important step in breast cancer (BC) growth and progression. Targeting angiogenesis was the most interesting by developed strategy in the treatment of HER2-negative BC. Bevacizumab is a monoclonal humanized antibody targeting the vascular endothelial growth factor (VEGF) the most potent factor implicated in tumor angiogenesis. It is the most developed targeted agent in HER2-negative MBC and showed the most interesting results in combination with chemotherapy. Currently, bevacizumab is the only approved targeted therapy (in Europe only) in the first line treatment of HER2-negative metastatic BC in combination with weekly paclitaxel. The aim of the present paper is to review the role of anti-angiogenic agents (targeted agents only) in the treatment of HER2-negative metastatic BC.

Keywords: Anti-angiogenic agents, bevacizumab, breast cancer, VEGF, VEGFR.

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Article Details

Year: 2014
Published on: 08 January, 2015
Page: [73 - 79]
Pages: 7
DOI: 10.2174/2211552803666141003221604
Price: $58

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