Design of a Novel Genetically Engineered Vaccine Against Mycobacterium leprae

Author(s): Chandiaserasekeran S. Devi, Prithwijit Sarkar, Shreya Bhagavatula, Shruti Chatterjee, Saumya D. Sisoudiya, Carolyn John, Vaithilingam Mohanasrinivasan

Journal Name: Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Under Re-organization)
Formerly Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents

Volume 14 , Issue 2 , 2014


Leprosy, caused by Mycobacterium leprae is a granulomatous disease of the peripheral nervous system, causing permanent damage to the nerves, skin and limbs. It mainly affects the people living below the poverty. The current immunization strategies against leprosy like the BCG vaccine face several limitations and thus there is a need for an effective counter measure. The main aim was to design a vaccine with a genetically modified strain of the non-pathogenic Mycobacterium smegmatis which over-expressed the immunedominant protein that would induce a strong, non-toxic cell-mediated immune response, and the production of memory cells would lead to successful immunization against leprosy.

Keywords: Mycobacterium leprae, leprosy, immuno-dominant antigen, Mycobacterium smegmatis, genetically engineered vaccine.

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Article Details

Year: 2014
Published on: 30 September, 2014
Page: [67 - 74]
Pages: 8
DOI: 10.2174/1871522214666141001004000
Price: $65

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