We report a case of isoniazid induced convulsions in 35 years old male alcoholic and smoker patient receiving
intensive phase therapy for pulmonary tuberculosis. A case was confirmed by accidental positive de-challenge and rechallenge
as well as ruled out other conditions. Use of isoniazid in alcoholic and smoker patient required a caution for
prevention of neurological adverse reactions. Pyridoxine should always be prescribed to such patients for the prevention
of such adverse reaction.
Keywords: Adverse drug reaction, alcohol, convulsions, isoniazid, pyridoxine deficiency, smoking.
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