Carbocyclic nucleoside analogs are highly biologically relevant compounds. A large variety of them already
serve as drugs or are investigated with this aim in mind. This review analyses syntheses of major types of carbocyclic
nucleoside derivatives including those of pharmacological interest. The emphasis of this review is on entecavir, a derivative
exhibiting selective activity at nanomolar level against hepatitis B virus.
The first subject of this review is the summary of nucleoside analogs, mainly classification and synthetic strategies employed
for the preparation of these derivatives. The second part focuses on the recent developments in the field of enanti
oselective approaches of synthesis of entecavir and related compounds. This paper covers the literature from 1992 to 2013.